How are suppositories formulated?

Conclusions Suppository formulation using water soluble bases are the ideal and are preferred for vaginal preparations Suppository formulations using lipid bases are preferred for hemorrhoid preparations but requires detailed knowledge of the raw materials used to manufacture suppositories.

What excipients are used in suppositories?

The hydrophilic class of suppositories include excipients that dissolve in the presence of water. These include primarily glycerin, gelatin and water soluble polymers such as PEG. Suppositories based on glycerin are most known for use in the treatment of constipation.

Which is the most common base material for rectal suppositories?

cocoa butter
The most frequently used suppository bases, especially: 1) cocoa butter. 2) hydrogenated fatty acids of vegetable oils, such as palm kernel oil and cottonseed oil. 3) compounds consisting of glycerides of higher- molecular-weight fatty acids, such as glyceryl monostearate and glyceryl monopalmitate.

What are the two types of rectal drugs?

Medication intended for rectal administration often comes in the form of a suppository or an enema. Suppositories (Fig 1a attached) are small, torpedo-shaped pellets that melt at body temperature, whereas enemas (Fig 1b, attached) are substances in liquid form designed for rectal administration.

Why is PEG used in suppositories?

PEGS, water soluble polymers of ethylene glycol, are used as suppository bases. These are tolerant to cations, to insoluble drugs and are relatively unaffected by the variations in pH. In contrast to PEG, other water soluble polymers have been reported to retard the drug release from the suppository (3).

What is the difference between a suppository and a pessary?

They are commonly used for vaginal and rectal complaints. The word suppository is derived from the Latin suppositorum, which means, “something placed beneath.” Pessary is an interchangeable term, referring specifically to a vaginal suppository.

What are the most important requirements for a suppository?

To allow for proper administration and drug delivery, suppositories require careful consideration of the following parameters: hardness, shape, drug solubilization, and melting range. Formulate an array of suppositories with our wide selection of matrix builders, solvents, and emulsifiers.

Which suppository base do not require lubrication?

Soap-glycerin base​

Can I use a capsule as a suppository?

If consistent use is necessary, almost any medication can be compounded into custom-made suppositories, gelatin-encased capsules, or microenemas of oral elixirs.

What type of drug delivery is a rectal suppository?

Suppositories are a medicated solid dosage form intended for insertion into the body orifices. Suppositories and creams are the two main modes of administration of drugs through the rectum. They are used to deliver both systemically acting and locally-acting medications.

When to use sustained release ( SR ) suppositories?

Sustained release (SR) suppositories are promising when oral route is inaccessible. SR suppositories were formulated in this study using different strategies. The first was to use HPMC as viscosity modifier and bioadhesive agent.

Which is the best formulation for a suppository?

What is the HPMC formula for atenolol suppositories?

HPMC or Sp 60/CH was used as release modifiers for Atenolol from suppositories made from PEG or WH15 bases. The suppositories formulations containing Sp 60/CH as 50% of the base weight could be considered as new suppository formulae.

Why are rectal suppositories used in cardiovascular emergencies?

Rectal administration showed one of the best routes involved in increasing drug absorption and bioavailability. It is considered a convenient route of drug administration especially in cardiovascular emergencies where the patient is unconscious and oral route and sometimes the parentral route are not possible.